When Is Cincinnati Reds Opening Day 2025. Fans, businesses, the reds and the cincinnati police department are preparing for opening day. Reds opening day is fast approaching, but lucky for fans like you, great tickets are still available, and at every price level, too!

The cincinnati reds will once again host the first series of the season at great american ballpark as they will take on the san fransisco. The reds’ first game of the season is thursday, march 27.